mel-28
C. elegans
Protein mel-28
What the model saw
Gene: mel-28 Organism: Caenorhabditis elegans Known functions: Protein mel-28. molecular adaptor activity.
View unredacted entry
Protein mel-28. molecular adaptor activity.
Solver output
MEL-28 (also known as ELYS in other organisms) is a nuclear pore complex component with molecular adaptor activity, involved in nuclear envelope reassembly and chromatin organization. While nuclear pore integrity is linked to genomic stability and has been implicated in aging in C. elegans, the annotation here is limited to "molecular adaptor activity," which is too broad to confidently assign a pro- or anti-longevity role. MEL-28's adaptor function could serve multiple pathways (nuclear transport, chromatin anchoring, kinetochore assembly), and its net effect on longevity is not clearly directional from this annotation alone. Without more specific pathway context—such as whether it modulates nuclear transport of longevity-related transcription factors or contributes to nuclear lamina integrity—a confident prediction cannot be made.
GenAge curators classify each gene's normal function as promoting (Pro-Longevity) or opposing (Anti-Longevity) longevity, based on synthesis across studies. Loss-of-function effects can vary from this depending on the manipulation.
Advisor judgment
The model predicted "unclear" with low confidence (0.35), but the ground truth is "anti_longevity." The model correctly identified MEL-28 as a nuclear pore complex component (ELYS homolog) and mentioned relevant pathways like nuclear envelope integrity and chromatin organization, which are plausible mechanisms for anti-longevity effects. However, the model failed to commit to a direction and instead hedged excessively. The mechanistic reasoning, while partially relevant, did not lead to the correct conclusion. The model's uncertainty was not warranted given that nuclear pore complex components in C. elegans have been studied in the context of aging, and a more informed prediction could have been made.
Raw API responses
solver
{
"reasoning": "MEL-28 (also known as ELYS in other organisms) is a nuclear pore complex component with molecular adaptor activity, involved in nuclear envelope reassembly and chromatin organization. While nuclear pore integrity is linked to genomic stability and has been implicated in aging in C. elegans, the annotation here is limited to \"molecular adaptor activity,\" which is too broad to confidently assign a pro- or anti-longevity role. MEL-28's adaptor function could serve multiple pathways (nuclear transport, chromatin anchoring, kinetochore assembly), and its net effect on longevity is not clearly directional from this annotation alone. Without more specific pathway context—such as whether it modulates nuclear transport of longevity-related transcription factors or contributes to nuclear lamina integrity—a confident prediction cannot be made.",
"confidence": 0.35,
"key_pathways": [
"nuclear pore complex assembly",
"chromatin organization",
"nuclear envelope integrity"
],
"mechanism_class": "unclear",
"longevity_influence": "unclear"
}advisor
{
"notes": "The model predicted \"unclear\" with low confidence (0.35), but the ground truth is \"anti_longevity.\" The model correctly identified MEL-28 as a nuclear pore complex component (ELYS homolog) and mentioned relevant pathways like nuclear envelope integrity and chromatin organization, which are plausible mechanisms for anti-longevity effects. However, the model failed to commit to a direction and instead hedged excessively. The mechanistic reasoning, while partially relevant, did not lead to the correct conclusion. The model's uncertainty was not warranted given that nuclear pore complex components in C. elegans have been studied in the context of aging, and a more informed prediction could have been made.",
"failure_mode": "appropriately_uncertain",
"answer_correct": false,
"mechanism_correct": false,
"reasoning_quality": 2,
"ground_truth_questionable": false
}