srl
D. melanogaster
spargel
What the model saw
Gene: srl Organism: Drosophila melanogaster Known functions: spargel. RNA binding. mRNA binding. nucleic acid binding. transcription coactivator activity. transcription coregulator activity.
View unredacted entry
spargel. RNA binding. mRNA binding. nucleic acid binding. transcription coactivator activity. transcription coregulator activity.
Solver output
The gene *srl* (spargel) in Drosophila melanogaster is the ortholog of mammalian PGC-1α (Peroxisome proliferator-activated receptor gamma coactivator 1-alpha), a master transcriptional coactivator of mitochondrial biogenesis. Its transcription coactivator/coregulator activity drives expression of nuclear-encoded mitochondrial genes, promoting oxidative phosphorylation capacity and mitochondrial function. Overexpression of spargel has been shown to extend lifespan in Drosophila, while loss-of-function reduces it, consistent with its role in maintaining mitochondrial homeostasis. The RNA binding and mRNA binding annotations further suggest post-transcriptional regulatory roles that may fine-tune mitochondrial gene expression. By sustaining mitochondrial biogenesis and function, srl directly counteracts the mitochondrial dysfunction hallmark of aging.
GenAge curators classify each gene's normal function as promoting (Pro-Longevity) or opposing (Anti-Longevity) longevity, based on synthesis across studies. Loss-of-function effects can vary from this depending on the manipulation.
Advisor judgment
The model correctly identified srl (spargel) as pro_longevity with high confidence (0.85). The mechanistic reasoning is excellent: correctly identifying srl as the Drosophila PGC-1α ortholog, explaining its role as a transcriptional coactivator of mitochondrial biogenesis, noting that overexpression extends lifespan while loss-of-function reduces it, and connecting the RNA binding annotations to post-transcriptional regulatory roles. The key pathways identified (PGC-1α/mitochondrial biogenesis, oxidative phosphorylation, AMPK/TOR-PGC1α axis) are all well-supported by the literature. This is a thorough and accurate prediction.
Raw API responses
solver
{
"reasoning": "The gene *srl* (spargel) in Drosophila melanogaster is the ortholog of mammalian PGC-1α (Peroxisome proliferator-activated receptor gamma coactivator 1-alpha), a master transcriptional coactivator of mitochondrial biogenesis. Its transcription coactivator/coregulator activity drives expression of nuclear-encoded mitochondrial genes, promoting oxidative phosphorylation capacity and mitochondrial function. Overexpression of spargel has been shown to extend lifespan in Drosophila, while loss-of-function reduces it, consistent with its role in maintaining mitochondrial homeostasis. The RNA binding and mRNA binding annotations further suggest post-transcriptional regulatory roles that may fine-tune mitochondrial gene expression. By sustaining mitochondrial biogenesis and function, srl directly counteracts the mitochondrial dysfunction hallmark of aging.",
"confidence": 0.85,
"key_pathways": [
"PGC-1α/mitochondrial biogenesis",
"oxidative phosphorylation",
"nutrient sensing (AMPK/TOR-PGC1α axis)"
],
"mechanism_class": "mitochondrial_dysfunction",
"longevity_influence": "pro_longevity"
}advisor
{
"notes": "The model correctly identified srl (spargel) as pro_longevity with high confidence (0.85). The mechanistic reasoning is excellent: correctly identifying srl as the Drosophila PGC-1α ortholog, explaining its role as a transcriptional coactivator of mitochondrial biogenesis, noting that overexpression extends lifespan while loss-of-function reduces it, and connecting the RNA binding annotations to post-transcriptional regulatory roles. The key pathways identified (PGC-1α/mitochondrial biogenesis, oxidative phosphorylation, AMPK/TOR-PGC1α axis) are all well-supported by the literature. This is a thorough and accurate prediction.",
"failure_mode": "correct",
"answer_correct": true,
"mechanism_correct": true,
"reasoning_quality": 5,
"ground_truth_questionable": false
}