RPL9A
S. cerevisiae
60S ribosomal protein uL6 RPL9A
What the model saw
Gene: RPL9A Organism: Saccharomyces cerevisiae Known functions: 60S ribosomal protein uL6 RPL9A. rRNA binding. structural constituent of ribosome.
View unredacted entry
60S ribosomal protein uL6 RPL9A. rRNA binding. structural constituent of ribosome.
Solver output
RPL9A encodes a structural component of the 60S ribosomal large subunit (uL6) that binds rRNA and is essential for ribosome assembly and translational capacity. In yeast, reduced ribosomal protein gene dosage — particularly of large subunit components — is well established to extend both replicative and chronological lifespan, largely through attenuation of TOR (TORC1)-driven protein synthesis. Deletion of many RPL genes mimics the pro-longevity effects of rapamycin or caloric restriction by decreasing global translation rates and redirecting resources toward stress resistance and autophagy. RPL9A's normal function therefore promotes ribosome biogenesis and high translational output, which is associated with accelerated aging in this nutrient-sensing axis. The TORC1–Sch9 pathway upregulates ribosome biogenesis, and high ribosomal activity opposes longevity by suppressing autophagy and stress-response programs.
GenAge curators classify each gene's normal function as promoting (Pro-Longevity) or opposing (Anti-Longevity) longevity, based on synthesis across studies. Loss-of-function effects can vary from this depending on the manipulation.
Advisor judgment
The model correctly predicted anti_longevity for RPL9A. The mechanistic reasoning is well-grounded: RPL9A is a 60S ribosomal protein, and deletion of large ribosomal subunit genes in yeast is well-established to extend lifespan by reducing translational output and attenuating TORC1 signaling. The model correctly identifies that the normal (wild-type) function of RPL9A promotes ribosome biogenesis and high translation, which opposes longevity — making it anti_longevity. The mechanism class "deregulated_nutrient_sensing" is a reasonable fit given the TORC1 connection, though "translational regulation" might be more precise. Overall, the reasoning is accurate and well-supported.
Raw API responses
solver
{
"reasoning": "RPL9A encodes a structural component of the 60S ribosomal large subunit (uL6) that binds rRNA and is essential for ribosome assembly and translational capacity. In yeast, reduced ribosomal protein gene dosage — particularly of large subunit components — is well established to extend both replicative and chronological lifespan, largely through attenuation of TOR (TORC1)-driven protein synthesis. Deletion of many RPL genes mimics the pro-longevity effects of rapamycin or caloric restriction by decreasing global translation rates and redirecting resources toward stress resistance and autophagy. RPL9A's normal function therefore promotes ribosome biogenesis and high translational output, which is associated with accelerated aging in this nutrient-sensing axis. The TORC1–Sch9 pathway upregulates ribosome biogenesis, and high ribosomal activity opposes longevity by suppressing autophagy and stress-response programs.",
"confidence": 0.72,
"key_pathways": [
"TORC1-driven ribosome biogenesis",
"translational regulation and protein synthesis",
"60S large ribosomal subunit assembly"
],
"mechanism_class": "deregulated_nutrient_sensing",
"longevity_influence": "anti_longevity"
}advisor
{
"notes": "The model correctly predicted anti_longevity for RPL9A. The mechanistic reasoning is well-grounded: RPL9A is a 60S ribosomal protein, and deletion of large ribosomal subunit genes in yeast is well-established to extend lifespan by reducing translational output and attenuating TORC1 signaling. The model correctly identifies that the normal (wild-type) function of RPL9A promotes ribosome biogenesis and high translation, which opposes longevity — making it anti_longevity. The mechanism class \"deregulated_nutrient_sensing\" is a reasonable fit given the TORC1 connection, though \"translational regulation\" might be more precise. Overall, the reasoning is accurate and well-supported.",
"failure_mode": "correct",
"answer_correct": true,
"mechanism_correct": true,
"reasoning_quality": 5,
"ground_truth_questionable": false
}