RPS11A
S. cerevisiae
40S ribosomal protein uS17 RPS11A
What the model saw
Gene: RPS11A Organism: Saccharomyces cerevisiae Known functions: 40S ribosomal protein uS17 RPS11A. structural constituent of ribosome.
View unredacted entry
40S ribosomal protein uS17 RPS11A. structural constituent of ribosome.
Solver output
RPS11A encodes the 40S ribosomal small subunit protein uS17, a structural constituent of the ribosome. Ribosome biogenesis and translational capacity are tightly coupled to the TOR (Target of Rapamycin) nutrient-sensing pathway in yeast; elevated ribosomal activity promotes anabolic growth signaling downstream of TORC1. Genetic reduction of ribosomal protein gene dosage — including deletion of one copy of small subunit proteins — is well-established to extend chronological and replicative lifespan in S. cerevisiae, consistent with the broader finding that dampening translation extends lifespan across model organisms. The normal function of RPS11A (promoting full ribosomal assembly and translation rates) therefore opposes longevity by sustaining high TORC1-driven protein synthesis. This places its mechanism within deregulated nutrient sensing, as ribosome abundance is a key readout and effector of TOR signaling.
GenAge curators classify each gene's normal function as promoting (Pro-Longevity) or opposing (Anti-Longevity) longevity, based on synthesis across studies. Loss-of-function effects can vary from this depending on the manipulation.
Advisor judgment
The model correctly predicted anti_longevity for RPS11A. The mechanistic reasoning is sound and well-articulated: ribosomal protein genes in yeast are well-known anti-longevity genes, as deletion of one copy of ribosomal protein genes (including small subunit proteins) extends lifespan. The connection to TOR/TORC1 nutrient sensing is appropriate, as ribosome biogenesis is a major downstream effector of TORC1 signaling. The model correctly identifies that the normal function of RPS11A (promoting ribosomal assembly and translation) opposes longevity. The confidence level of 0.75 is reasonable given the well-established literature on ribosomal protein deletions extending yeast lifespan.
Raw API responses
solver
{
"reasoning": "RPS11A encodes the 40S ribosomal small subunit protein uS17, a structural constituent of the ribosome. Ribosome biogenesis and translational capacity are tightly coupled to the TOR (Target of Rapamycin) nutrient-sensing pathway in yeast; elevated ribosomal activity promotes anabolic growth signaling downstream of TORC1. Genetic reduction of ribosomal protein gene dosage — including deletion of one copy of small subunit proteins — is well-established to extend chronological and replicative lifespan in S. cerevisiae, consistent with the broader finding that dampening translation extends lifespan across model organisms. The normal function of RPS11A (promoting full ribosomal assembly and translation rates) therefore opposes longevity by sustaining high TORC1-driven protein synthesis. This places its mechanism within deregulated nutrient sensing, as ribosome abundance is a key readout and effector of TOR signaling.",
"confidence": 0.75,
"key_pathways": [
"TOR/TORC1 nutrient sensing",
"ribosome biogenesis",
"translational regulation"
],
"mechanism_class": "deregulated_nutrient_sensing",
"longevity_influence": "anti_longevity"
}advisor
{
"notes": "The model correctly predicted anti_longevity for RPS11A. The mechanistic reasoning is sound and well-articulated: ribosomal protein genes in yeast are well-known anti-longevity genes, as deletion of one copy of ribosomal protein genes (including small subunit proteins) extends lifespan. The connection to TOR/TORC1 nutrient sensing is appropriate, as ribosome biogenesis is a major downstream effector of TORC1 signaling. The model correctly identifies that the normal function of RPS11A (promoting ribosomal assembly and translation) opposes longevity. The confidence level of 0.75 is reasonable given the well-established literature on ribosomal protein deletions extending yeast lifespan.",
"failure_mode": "correct",
"answer_correct": true,
"mechanism_correct": true,
"reasoning_quality": 5,
"ground_truth_questionable": false
}