PEX9
S. cerevisiae
Pex9p
What the model saw
Gene: PEX9 Organism: Saccharomyces cerevisiae Known functions: Pex9p. peroxisome matrix targeting signal-1 binding. protein-macromolecule adaptor activity.
View unredacted entry
Pex9p. peroxisome matrix targeting signal-1 binding. protein-macromolecule adaptor activity.
Solver output
PEX9 encodes a peroxin in S. cerevisiae that functions as a peroxisome matrix targeting signal-1 (PTS1) receptor/adaptor, facilitating import of PTS1-bearing proteins into the peroxisome matrix. Proper peroxisomal protein import is essential for peroxisome biogenesis and function, including fatty acid β-oxidation and reactive oxygen species detoxification via catalase. Functional peroxisomes are critical for metabolic homeostasis and redox balance, both of which are linked to lifespan in yeast. Loss of peroxisomal import machinery leads to peroxisome dysfunction, accumulation of misfolded or mistargeted proteins, and impaired lipid metabolism — all of which are associated with accelerated aging. PEX9 acts as a condition-specific PTS1 receptor (active under oleate-inducing conditions), so its role supports peroxisomal proteostasis and organelle integrity, placing it in a pro-longevity context analogous to other peroxisome biogenesis factors.
GenAge curators classify each gene's normal function as promoting (Pro-Longevity) or opposing (Anti-Longevity) longevity, based on synthesis across studies. Loss-of-function effects can vary from this depending on the manipulation.
Advisor judgment
The model predicted pro_longevity but the ground truth is anti_longevity. The model's reasoning assumes that because PEX9 supports peroxisome function, it must be pro-longevity. However, the ground truth indicates PEX9 is anti-longevity, meaning its deletion or loss likely extends lifespan. The model's mechanistic reasoning is plausible on the surface but leads to the wrong conclusion. PEX9 is a condition-specific (oleate-induced) PTS1 receptor, and its anti-longevity classification suggests that peroxisomal activity mediated by PEX9 may actually promote aging rather than prevent it — possibly through ROS production or other metabolic effects. The model's confidence of 0.55 is relatively low, but it still committed to the wrong answer. The reasoning quality is poor because it failed to consider that peroxisomal activity could be detrimental to longevity in certain contexts.
Raw API responses
solver
{
"reasoning": "PEX9 encodes a peroxin in S. cerevisiae that functions as a peroxisome matrix targeting signal-1 (PTS1) receptor/adaptor, facilitating import of PTS1-bearing proteins into the peroxisome matrix. Proper peroxisomal protein import is essential for peroxisome biogenesis and function, including fatty acid β-oxidation and reactive oxygen species detoxification via catalase. Functional peroxisomes are critical for metabolic homeostasis and redox balance, both of which are linked to lifespan in yeast. Loss of peroxisomal import machinery leads to peroxisome dysfunction, accumulation of misfolded or mistargeted proteins, and impaired lipid metabolism — all of which are associated with accelerated aging. PEX9 acts as a condition-specific PTS1 receptor (active under oleate-inducing conditions), so its role supports peroxisomal proteostasis and organelle integrity, placing it in a pro-longevity context analogous to other peroxisome biogenesis factors.",
"confidence": 0.55,
"key_pathways": [
"peroxisome matrix protein import (PTS1 pathway)",
"peroxisome biogenesis",
"fatty acid beta-oxidation and ROS detoxification"
],
"mechanism_class": "disabled_macroautophagy",
"longevity_influence": "pro_longevity"
}advisor
{
"notes": "The model predicted pro_longevity but the ground truth is anti_longevity. The model's reasoning assumes that because PEX9 supports peroxisome function, it must be pro-longevity. However, the ground truth indicates PEX9 is anti-longevity, meaning its deletion or loss likely extends lifespan. The model's mechanistic reasoning is plausible on the surface but leads to the wrong conclusion. PEX9 is a condition-specific (oleate-induced) PTS1 receptor, and its anti-longevity classification suggests that peroxisomal activity mediated by PEX9 may actually promote aging rather than prevent it — possibly through ROS production or other metabolic effects. The model's confidence of 0.55 is relatively low, but it still committed to the wrong answer. The reasoning quality is poor because it failed to consider that peroxisomal activity could be detrimental to longevity in certain contexts.",
"failure_mode": "confident_wrong",
"answer_correct": false,
"mechanism_correct": false,
"reasoning_quality": 2,
"ground_truth_questionable": false
}