daf-15
C. elegans
Raptor N-terminal CASPase-like domain-containing protein
What the model saw
Gene: daf-15 Organism: Caenorhabditis elegans Known functions: Raptor N-terminal CASPase-like domain-containing protein. protein kinase activator activity. protein-macromolecule adaptor activity.
View unredacted entry
Raptor N-terminal CASPase-like domain-containing protein. protein kinase activator activity. protein-macromolecule adaptor activity.
Solver output
DAF-15 is the C. elegans ortholog of Raptor (Regulatory-Associated Protein of mTOR), a defining scaffolding subunit of the TORC1 complex. Its Raptor N-terminal CASPase-like domain and protein-macromolecule adaptor activity mediate substrate recruitment to TOR kinase, while its protein kinase activator activity reflects its role in stimulating mTORC1 kinase output. Active TORC1 signaling suppresses autophagy, promotes anabolic metabolism, and inhibits stress-response programs — all of which are associated with shortened lifespan in C. elegans. Loss-of-function of daf-15/Raptor reduces TORC1 activity and extends lifespan, placing it downstream of nutrient-sensing inputs and upstream of S6 kinase (rsks-1) and 4E-BP (ifg-1) effectors. Thus, the normal (wild-type) function of DAF-15 promotes TORC1 activity and opposes longevity.
GenAge curators classify each gene's normal function as promoting (Pro-Longevity) or opposing (Anti-Longevity) longevity, based on synthesis across studies. Loss-of-function effects can vary from this depending on the manipulation.
Advisor judgment
The model correctly identified daf-15 as anti_longevity with high confidence (0.88). The mechanistic reasoning is excellent: correctly identifies DAF-15 as the C. elegans Raptor ortholog, component of TORC1, explains how its loss-of-function extends lifespan by reducing TORC1 activity, and correctly names downstream effectors (rsks-1/S6K and ifg-1/4E-BP). The mechanism class "deregulated_nutrient_sensing" is appropriate. All aspects of the prediction are accurate and well-reasoned.
Raw API responses
solver
{
"reasoning": "DAF-15 is the C. elegans ortholog of Raptor (Regulatory-Associated Protein of mTOR), a defining scaffolding subunit of the TORC1 complex. Its Raptor N-terminal CASPase-like domain and protein-macromolecule adaptor activity mediate substrate recruitment to TOR kinase, while its protein kinase activator activity reflects its role in stimulating mTORC1 kinase output. Active TORC1 signaling suppresses autophagy, promotes anabolic metabolism, and inhibits stress-response programs — all of which are associated with shortened lifespan in C. elegans. Loss-of-function of daf-15/Raptor reduces TORC1 activity and extends lifespan, placing it downstream of nutrient-sensing inputs and upstream of S6 kinase (rsks-1) and 4E-BP (ifg-1) effectors. Thus, the normal (wild-type) function of DAF-15 promotes TORC1 activity and opposes longevity.",
"confidence": 0.88,
"key_pathways": [
"mTORC1/TORC1 nutrient sensing",
"TOR-S6K signaling axis",
"autophagy suppression"
],
"mechanism_class": "deregulated_nutrient_sensing",
"longevity_influence": "anti_longevity"
}advisor
{
"notes": "The model correctly identified daf-15 as anti_longevity with high confidence (0.88). The mechanistic reasoning is excellent: correctly identifies DAF-15 as the C. elegans Raptor ortholog, component of TORC1, explains how its loss-of-function extends lifespan by reducing TORC1 activity, and correctly names downstream effectors (rsks-1/S6K and ifg-1/4E-BP). The mechanism class \"deregulated_nutrient_sensing\" is appropriate. All aspects of the prediction are accurate and well-reasoned.",
"failure_mode": "correct",
"answer_correct": true,
"mechanism_correct": true,
"reasoning_quality": 5,
"ground_truth_questionable": false
}