HRB1
S. cerevisiae
mRNA-binding protein
What the model saw
Gene: HRB1 Organism: Saccharomyces cerevisiae Known functions: mRNA-binding protein. RNA binding. chromatin binding. mRNA binding. nucleic acid binding.
View unredacted entry
mRNA-binding protein. RNA binding. chromatin binding. mRNA binding. nucleic acid binding.
Solver output
HRB1 encodes an mRNA-binding protein with annotated functions in RNA binding, mRNA binding, chromatin binding, and nucleic acid binding. While chromatin binding hints at potential roles in epigenetic regulation, the primary annotated function is post-transcriptional mRNA binding, which does not map cleanly to a specific pro- or anti-longevity pathway in yeast. mRNA-binding proteins can influence longevity through diverse mechanisms—including stress granule formation, translational regulation, or mRNA stability—but without more specific pathway information (e.g., involvement in TOR-mediated translational repression, stress response, or a defined chromatin-remodeling complex), the directionality of its effect on lifespan cannot be confidently determined. The dual chromatin and mRNA binding annotations suggest possible roles in co-transcriptional RNA processing, but this alone is insufficient to assign a clear pro- or anti-longevity role.
GenAge curators classify each gene's normal function as promoting (Pro-Longevity) or opposing (Anti-Longevity) longevity, based on synthesis across studies. Loss-of-function effects can vary from this depending on the manipulation.
Advisor judgment
The model predicted "unclear" with low confidence (0.35), but the ground truth is "anti_longevity." The model's reasoning is plausible given the limited information provided (mRNA-binding protein with chromatin binding), but it failed to commit to the correct answer. The mechanism class of "epigenetic_alterations" is questionable given that HRB1 is primarily an mRNA-binding protein. The model's uncertainty was somewhat reasonable given the sparse functional annotations, but it still missed the correct classification. The reasoning quality is modest — it correctly identifies the ambiguity but doesn't leverage any deeper knowledge about HRB1's known role in yeast longevity (deletion of HRB1 extends lifespan, making it anti-longevity).
Raw API responses
solver
{
"reasoning": "HRB1 encodes an mRNA-binding protein with annotated functions in RNA binding, mRNA binding, chromatin binding, and nucleic acid binding. While chromatin binding hints at potential roles in epigenetic regulation, the primary annotated function is post-transcriptional mRNA binding, which does not map cleanly to a specific pro- or anti-longevity pathway in yeast. mRNA-binding proteins can influence longevity through diverse mechanisms—including stress granule formation, translational regulation, or mRNA stability—but without more specific pathway information (e.g., involvement in TOR-mediated translational repression, stress response, or a defined chromatin-remodeling complex), the directionality of its effect on lifespan cannot be confidently determined. The dual chromatin and mRNA binding annotations suggest possible roles in co-transcriptional RNA processing, but this alone is insufficient to assign a clear pro- or anti-longevity role.",
"confidence": 0.35,
"key_pathways": [
"mRNA binding and post-transcriptional regulation",
"chromatin-associated RNA processing",
"nucleic acid binding"
],
"mechanism_class": "epigenetic_alterations",
"longevity_influence": "unclear"
}advisor
{
"notes": "The model predicted \"unclear\" with low confidence (0.35), but the ground truth is \"anti_longevity.\" The model's reasoning is plausible given the limited information provided (mRNA-binding protein with chromatin binding), but it failed to commit to the correct answer. The mechanism class of \"epigenetic_alterations\" is questionable given that HRB1 is primarily an mRNA-binding protein. The model's uncertainty was somewhat reasonable given the sparse functional annotations, but it still missed the correct classification. The reasoning quality is modest — it correctly identifies the ambiguity but doesn't leverage any deeper knowledge about HRB1's known role in yeast longevity (deletion of HRB1 extends lifespan, making it anti-longevity).",
"failure_mode": "appropriately_uncertain",
"answer_correct": false,
"mechanism_correct": false,
"reasoning_quality": 2,
"ground_truth_questionable": false
}