DCW1
S. cerevisiae
putative mannan endo-1,6-alpha-mannosidase
What the model saw
Gene: DCW1 Organism: Saccharomyces cerevisiae Known functions: putative mannan endo-1,6-alpha-mannosidase. mannan endo-1,6-alpha-mannosidase activity.
View unredacted entry
putative mannan endo-1,6-alpha-mannosidase. mannan endo-1,6-alpha-mannosidase activity.
Solver output
DCW1 encodes a putative mannan endo-1,6-alpha-mannosidase involved in cell wall mannan remodeling in S. cerevisiae. This enzymatic activity cleaves internal alpha-1,6-mannose linkages in the yeast cell wall polysaccharide mannan. While cell wall integrity is important for yeast fitness, the specific contribution of mannan endomannosidase activity to longevity pathways (such as TOR signaling, autophagy, or proteostasis) is not well established. Cell wall remodeling enzymes are not canonically linked to pro- or anti-longevity mechanisms, and there is insufficient evidence to connect this specific glycosidase activity to a defined aging hallmark in a directional manner.
GenAge curators classify each gene's normal function as promoting (Pro-Longevity) or opposing (Anti-Longevity) longevity, based on synthesis across studies. Loss-of-function effects can vary from this depending on the manipulation.
Advisor judgment
The model predicted "unclear" with low confidence (0.35), while the ground truth is "anti_longevity." The model's reasoning about DCW1's role in cell wall mannan remodeling is plausible but doesn't connect to any anti-longevity mechanism. The model correctly identified the enzymatic function but failed to determine the directional longevity influence. This is a case where the model was appropriately uncertain given limited information, but still got the answer wrong. The ground truth designation as anti_longevity suggests that deletion of DCW1 extends lifespan (i.e., the gene normally works against longevity), which the model did not predict.
Raw API responses
solver
{
"reasoning": "DCW1 encodes a putative mannan endo-1,6-alpha-mannosidase involved in cell wall mannan remodeling in S. cerevisiae. This enzymatic activity cleaves internal alpha-1,6-mannose linkages in the yeast cell wall polysaccharide mannan. While cell wall integrity is important for yeast fitness, the specific contribution of mannan endomannosidase activity to longevity pathways (such as TOR signaling, autophagy, or proteostasis) is not well established. Cell wall remodeling enzymes are not canonically linked to pro- or anti-longevity mechanisms, and there is insufficient evidence to connect this specific glycosidase activity to a defined aging hallmark in a directional manner.",
"confidence": 0.35,
"key_pathways": [
"cell wall mannan remodeling",
"glycosylphosphatidylinositol (GPI)-anchored protein function",
"cell wall integrity signaling"
],
"mechanism_class": "other",
"longevity_influence": "unclear"
}advisor
{
"notes": "The model predicted \"unclear\" with low confidence (0.35), while the ground truth is \"anti_longevity.\" The model's reasoning about DCW1's role in cell wall mannan remodeling is plausible but doesn't connect to any anti-longevity mechanism. The model correctly identified the enzymatic function but failed to determine the directional longevity influence. This is a case where the model was appropriately uncertain given limited information, but still got the answer wrong. The ground truth designation as anti_longevity suggests that deletion of DCW1 extends lifespan (i.e., the gene normally works against longevity), which the model did not predict.",
"failure_mode": "appropriately_uncertain",
"answer_correct": false,
"mechanism_correct": false,
"reasoning_quality": 2,
"ground_truth_questionable": false
}