cm
D. melanogaster
carmine
What the model saw
Gene: cm Organism: Drosophila melanogaster Known functions: carmine. cargo adaptor activity. clathrin-cargo adaptor activity.
View unredacted entry
carmine. cargo adaptor activity. clathrin-cargo adaptor activity.
Solver output
The gene "cm" (carmine) in Drosophila melanogaster is annotated with cargo adaptor activity and clathrin-cargo adaptor activity, meaning it facilitates the selective packaging of membrane proteins and receptors into clathrin-coated vesicles during endocytosis. While clathrin-mediated endocytosis is critical for receptor downregulation and intracellular trafficking, the specific longevity impact depends heavily on which cargo(es) cm adapts. Clathrin-cargo adaptors can influence signaling pathways relevant to aging (e.g., insulin/IGF-1 receptor internalization, which could modulate IIS pathway activity), but without knowledge of the specific cargo(es) targeted by carmine, the net effect on longevity is ambiguous. The function is too cargo-specific to confidently assign a pro- or anti-longevity role without additional context.
GenAge curators classify each gene's normal function as promoting (Pro-Longevity) or opposing (Anti-Longevity) longevity, based on synthesis across studies. Loss-of-function effects can vary from this depending on the manipulation.
Advisor judgment
The model predicted "unclear" while the ground truth is "pro_longevity." The model's reasoning about clathrin-mediated endocytosis and cargo adaptor activity is plausible but speculative, and the model failed to commit to the correct answer. The model's uncertainty is understandable given the limited information provided (only gene name and GO annotations), but it still got the answer wrong. The mechanistic reasoning about IIS pathway modulation via receptor internalization is speculative and not confirmed as the actual mechanism. The model appropriately flagged uncertainty but was unable to arrive at the correct classification.
Raw API responses
solver
{
"reasoning": "The gene \"cm\" (carmine) in Drosophila melanogaster is annotated with cargo adaptor activity and clathrin-cargo adaptor activity, meaning it facilitates the selective packaging of membrane proteins and receptors into clathrin-coated vesicles during endocytosis. While clathrin-mediated endocytosis is critical for receptor downregulation and intracellular trafficking, the specific longevity impact depends heavily on which cargo(es) cm adapts. Clathrin-cargo adaptors can influence signaling pathways relevant to aging (e.g., insulin/IGF-1 receptor internalization, which could modulate IIS pathway activity), but without knowledge of the specific cargo(es) targeted by carmine, the net effect on longevity is ambiguous. The function is too cargo-specific to confidently assign a pro- or anti-longevity role without additional context.",
"confidence": 0.35,
"key_pathways": [
"clathrin-mediated endocytosis",
"receptor internalization and trafficking",
"insulin/IGF-1 signaling (potential cargo)"
],
"mechanism_class": "altered_intercellular_communication",
"longevity_influence": "unclear"
}advisor
{
"notes": "The model predicted \"unclear\" while the ground truth is \"pro_longevity.\" The model's reasoning about clathrin-mediated endocytosis and cargo adaptor activity is plausible but speculative, and the model failed to commit to the correct answer. The model's uncertainty is understandable given the limited information provided (only gene name and GO annotations), but it still got the answer wrong. The mechanistic reasoning about IIS pathway modulation via receptor internalization is speculative and not confirmed as the actual mechanism. The model appropriately flagged uncertainty but was unable to arrive at the correct classification.",
"failure_mode": "appropriately_uncertain",
"answer_correct": false,
"mechanism_correct": false,
"reasoning_quality": 2,
"ground_truth_questionable": false
}